Article 7215

Title of the article



Kruchinina Anastasya Dmitrievna, Assistant, sub-department of general biology and biochemistry, Penza State University (40 Krasnaya street, Penza, Russia),

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Background. The study is aimed at exploring possible changes in peptidyl-dipeptidase A and lysine carboxypeptidase activitу in the serum of rats after a single injection of the reboxetine antidepressant.
Materials and methods. Selective norepinephrine reuptake inhibitor reboxetine is a common treatment for patients with depression. Changes in the activity of peptidyl- dipeptidase A and lysine carboxypeptidase affects the level of regulatory peptides associated with the disease development. The enzyme activitу was determined fotometrically in rat serum after 12, 24, 72 hours since a single injection of reboxetine.
Results. Depression is associated with changes in the level of regulatory peptides in the blood serum. It has been revealed that reboxetine injection effects the activity of peptidyl-dipeptidase A and lysine carboxypeptidase – enzymes regulating the level of biologically active peptides in the blood.
Conclusions. Thus, сhanges in enzyme activity can be one of the mechanisms for regulation of the level of biologically active peptides at the disease correction.

Key words

depression, reboxetine, monoamines, regulatory peptides, peptidyldipeptidase A, lysine carboxypeptidase, norepinephrine.

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Дата создания: 27.08.2015 11:32
Дата обновления: 24.09.2015 15:56